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The following term was not found in PubMed: ENSG00000141279
Page 1
Systematic Review and Meta-Analyses of Aminopeptidases as Prognostic Biomarkers in Amyotrophic Lateral Sclerosis.
Teruel-Peña B, Gómez-Urquiza JL, Suleiman-Martos N, Prieto I, García-Cózar FJ, Ramírez-Sánchez M, Fernández-Martos C, Domínguez-Vías G. Teruel-Peña B, et al. Int J Mol Sci. 2023 Apr 12;24(8):7169. doi: 10.3390/ijms24087169. Int J Mol Sci. 2023. PMID: 37108335 Free PMC article. Review.
A total of 16 studies were included in this systematic review, where a series of aminopeptidases could be related to ALS and could be promising biomarkers (DPP1, DPP2, DPP4, LeuAP, pGluAP, and PSA/NPEPPS). The literature reported the association of single-nucleotide polymo …
A total of 16 studies were included in this systematic review, where a series of aminopeptidases could be related to ALS and could be promis …
Genetic associations and functional characterization of M1 aminopeptidases and immune-mediated diseases.
Agrawal N, Brown MA. Agrawal N, et al. Genes Immun. 2014 Dec;15(8):521-7. doi: 10.1038/gene.2014.46. Epub 2014 Aug 21. Genes Immun. 2014. PMID: 25142031 Review.
Endosplasmic reticulum aminopeptidase 1 (ERAP1), endoplasmic reticulum aminopeptidase 2 (ERAP2) and puromycin-sensitive aminopeptidase (NPEPPS) are key zinc metallopeptidases that belong to the oxytocinase subfamily of M1 aminopeptidase family. NPEPPS catalyzes the …
Endosplasmic reticulum aminopeptidase 1 (ERAP1), endoplasmic reticulum aminopeptidase 2 (ERAP2) and puromycin-sensitive aminopeptidase (N …
Revisiting MHC genes in spondyloarthritis.
Breban M, Costantino F, André C, Chiocchia G, Garchon HJ. Breban M, et al. Curr Rheumatol Rep. 2015 Jun;17(6):516. doi: 10.1007/s11926-015-0516-1. Curr Rheumatol Rep. 2015. PMID: 25903667 Review.
Interestingly, some of those new genes, such as ERAP1, ERAP2, and NPEPPS, code for aminopeptidases that are involved in MHC class I presentation and were shown to interact with HLA-B27....
Interestingly, some of those new genes, such as ERAP1, ERAP2, and NPEPPS, code for aminopeptidases that are involved in MHC class I p …
Whole-exome sequencing study identifies four novel gene loci associated with diabetic kidney disease.
Pan Y, Sun X, Mi X, Huang Z, Hsu Y, Hixson JE, Munzy D, Metcalf G, Franceschini N, Tin A, Köttgen A, Francis M; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium TOPMed Kidney Function Working Group; Brody JA, Kestenbaum B, Sitlani CM, Mychaleckyj JC, Kramer H, Lange LA, Guo X, Hwang SJ, Irvin MR, Smith JA, Yanek LR, Vaidya D, Chen YI, Fornage M, Lloyd-Jones DM, Hou L, Mathias RA, Mitchell BD, Peyser PA, Kardia SLR, Arnett DK, Correa A, Raffield LM, Vasan RS, Cupple LA, Levy D, Kaplan RC, North KE, Rotter JI, Kooperberg C, Reiner AP, Psaty BM, Tracy RP, Gibbs RA, Morrison AC, Feldman H, Boerwinkle E, He J, Kelly TN; CRIC Study Investigators. Pan Y, et al. Hum Mol Genet. 2023 Mar 6;32(6):1048-1060. doi: 10.1093/hmg/ddac290. Hum Mol Genet. 2023. PMID: 36444934 Free PMC article.
Aggregate gene-based analyses further identified ERAP2 (P = 4.03 10-8) and NPEPPS (P = 1.51 10-7), which are both expressed in the kidney and implicated in renin-angiotensin-aldosterone system modulated immune response. ...
Aggregate gene-based analyses further identified ERAP2 (P = 4.03 10-8) and NPEPPS (P = 1.51 10-7), which are both expressed in the ki …
Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice.
Kudo LC, Parfenova L, Ren G, Vi N, Hui M, Ma Z, Lau K, Gray M, Bardag-Gorce F, Wiedau-Pazos M, Hui KS, Karsten SL. Kudo LC, et al. Hum Mol Genet. 2011 May 1;20(9):1820-33. doi: 10.1093/hmg/ddr065. Epub 2011 Feb 14. Hum Mol Genet. 2011. PMID: 21320871
Here, to examine the effects of PSA/NPEPPS overexpression in vivo in the mammalian system, we generated and crossed BAC-PSA/NPEPPS transgenic mice with the TAU(P301L) mouse model of neurodegeneration. PSA/NPEPPS activity in the brain and peripheral tissues of …
Here, to examine the effects of PSA/NPEPPS overexpression in vivo in the mammalian system, we generated and crossed BAC-PSA/NPEPPS …
NPEPPS Is a Druggable Driver of Platinum Resistance.
Jones RT, Scholtes M, Goodspeed A, Akbarzadeh M, Mohapatra S, Feldman LE, Vekony H, Jean A, Tilton CB, Orman MV, Romal S, Deiter C, Kan TW, Xander N, Araki SP, Joshi M, Javaid M, Clambey ET, Layer R, Laajala TD, Parker SJ, Mahmoudi T, Zuiverloon TCM, Theodorescu D, Costello JC. Jones RT, et al. Cancer Res. 2024 Mar 27:OF1-OF20. doi: 10.1158/0008-5472.CAN-23-1976. Online ahead of print. Cancer Res. 2024. PMID: 38535994
Conversely, overexpression of NPEPPS in sensitive cells increased cisplatin resistance. NPEPPS affected treatment response by regulating intracellular cisplatin concentrations. ...Our data present NPEPPS as a druggable driver of cisplatin resistance by regula …
Conversely, overexpression of NPEPPS in sensitive cells increased cisplatin resistance. NPEPPS affected treatment response by …
Primary cutaneous apocrine carcinoma with RARA::NPEPPS fusion.
Lenskaya V, Yang RK, Cho WC. Lenskaya V, et al. J Cutan Pathol. 2024 Jun;51(6):419-423. doi: 10.1111/cup.14607. Epub 2024 Mar 12. J Cutan Pathol. 2024. PMID: 38468567
We present a unique case of primary cutaneous apocrine carcinoma harboring RARA::NPEPPS fusion, broadening the spectrum of fusion-associated cutaneous adnexal neoplasms. ...The immunoprofile and clinical and radiographic absence of any internal malignancy, including breast …
We present a unique case of primary cutaneous apocrine carcinoma harboring RARA::NPEPPS fusion, broadening the spectrum of fusion-ass …
Puromycin, a selective inhibitor of PSA acts as a substrate for other M1 family aminopeptidases: Biochemical and structural basis.
Reddi R, Ganji RJ, Marapaka AK, Bala SC, Yerra NV, Haque N, Addlagatta A. Reddi R, et al. Int J Biol Macromol. 2020 Dec 15;165(Pt A):1373-1381. doi: 10.1016/j.ijbiomac.2020.10.035. Epub 2020 Oct 9. Int J Biol Macromol. 2020. PMID: 33045297
Puromycin sensitive aminopeptidase (PSA or NPEPPS) is a M1 class aminopeptidase is selectively inhibited by the natural product puromycin, an aminonucleoside antibiotic produced by the bacterium Streptomyces alboniger. ...
Puromycin sensitive aminopeptidase (PSA or NPEPPS) is a M1 class aminopeptidase is selectively inhibited by the natural product purom …
Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study.
Muraoka S, Jedrychowski MP, Yanamandra K, Ikezu S, Gygi SP, Ikezu T. Muraoka S, et al. Cells. 2020 Aug 25;9(9):1959. doi: 10.3390/cells9091959. Cells. 2020. PMID: 32854315 Free PMC article.
Quantitative proteomics analysis, moreover, showed that EVs expressed 1284 unique proteins in AD, MCI and CTRL groups. Statistical analysis identified three proteins-HSPA1A, NPEPPS, and PTGFRN-involved in AD progression. In addition, the PTGFRN showed a moderate correlatio …
Quantitative proteomics analysis, moreover, showed that EVs expressed 1284 unique proteins in AD, MCI and CTRL groups. Statistical analysis …
Identification and characterization of microRNA in the lung tissue of pigs with different susceptibilities to PCV2 infection.
Zhang P, Wang L, Li Y, Jiang P, Wang Y, Wang P, Kang L, Wang Y, Sun Y, Jiang Y. Zhang P, et al. Vet Res. 2018 Feb 15;49(1):18. doi: 10.1186/s13567-018-0512-3. Vet Res. 2018. PMID: 29448950 Free PMC article.
Among the up-regulated miRNA, ssc-miR-122 can repress the protein expression and viral DNA replication of PCV2 and down-regulate the expression of the nuclear factor of activated T-cells 5 (NFAT5) and aminopeptidase puromycin sensitive (NPEPPS) by binding to their 3' untra …
Among the up-regulated miRNA, ssc-miR-122 can repress the protein expression and viral DNA replication of PCV2 and down-regulate the express …
25 results